Author's response to reviews Title: Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome Authors:

Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome

BACKGROUND Gilbert syndrome is caused by defects in bilirubin UDP-glucuronosyltransferase (UGT1A1). The most common variation believed to be involved is A(TA)7TAA. Although several polymorphisms have been found to link with A(TA)7TAA, the combined effect of regulatory polymorphisms in the development of Gilbert syndrome remains unclear. METHODS In an analysis of 15 patients and 60 normal subj...

Author's response to reviews Title: Sox2 suppresses the invasiveness of breast cancer cells via a mechanism that is dependent on Twist1 and the status of Sox2 transcription activity Authors:

Author's response to reviews Title: Voice disorders and mental health in teachers: a cross-sectional nationwide study Authors:

Title: Voice disorders and mental health in teachers: a cross-sectional nationwide study Authors: Elena Nerrière ([email protected]) Marie-Noël Vercambre ([email protected]) Fabien Gilbert ([email protected]) Viviane Kovess-Masféty

P-216: Common Polymorphisms of StAR Gene Are Not Associated with Polycystic Ovary Syndrome in Iranian Patients

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting 5-10% of reproductive aged women. High levels of androgen hormone can be accounted as the most important symptoms in PCOS. Androgen is the precursor of steroid biosynthesis in ovary. The transport of cholesterol to the inner mitochondrial membrane through StAR protein is also necessary for andr...

UGT1A1 gene linkage analysis: application of polymorphic markers rs4148326/rs4124874 in the Iranian population

Objective(s): Mutations in the UGT1A1 gene are responsible for hyperbilirubinemia syndromes including Crigler-Najjar type 1 and 2 and Gilbert syndrome. In view of the genetic heterogeneity and involvement of large numbers of the disease causing mutations, the application of polymorphic markers in the UGTA1 gene could be useful in molecular diagnosis of the disease. Materials and Methods: In the...